The Clinical Usefulness of SPIO-MRI in Detection and Staging of Hepatocellular Carcinoma / 대한간학회지
The Korean Journal of Hepatology
;
: 17-24, 2003.
Article
in Korean
| WPRIM
| ID: wpr-199783
ABSTRACT
BACKGROUND/AIMS:
It is still unclear whether Super Paramagnetic Iron Oxide-Magnetic Resonance Imaging (SPIO-MRI) is a clinically useful imaging modality for patients with hepatocellular carcinoma (HCC). This study searched for the clinical usefulness and limitations of SPIO-MRI with respect to tumor detection capacity, false positive and negative rate, and early recurrence rate.METHODS:
From December 1999 to February 2001, 218 patients who were surgical candidates by 3-phase dynamic helical CT (3dHCT) were enrolled. We reviewed the medical records and radiologic findings, retrospectively, and postulated the post-operative pathologic findings and the early recurrences within 3 months as the standards for the true positive lesion.RESULTS:
The mean number of nodules detected by SPIO-MRI was significantly more numerous than that of 3dHCT (p<0.01). Modifications of treatment strategy due to the discordant findings between SPIO-MRI and 3dHCT for tumor resectability were observed in 22 (10.1%) out of 218 patients. Early recurrences were observed in 10 patients (7.8%). The false positive and negative rates of SPIO-MRI were 6.3% and 13.3%, respectively.CONCLUSIONS:
We demonstrated that the tumor detection rate of SPIO-MRI was better than that of 3dHCT. Given the relatively acceptable false positive and negative rates, SPIO-MRI could be an appropriate preoperative imaging modality for patients with HCCs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxides
/
Magnetic Resonance Imaging
/
Carcinoma, Hepatocellular
/
Contrast Media
/
Tomography, Spiral Computed
/
Ferrosoferric Oxide
/
False Negative Reactions
/
False Positive Reactions
/
Iron
/
Liver Neoplasms
Type of study:
Diagnostic study
/
Practice guideline
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Hepatology
Year:
2003
Type:
Article
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