Identification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight
Experimental & Molecular Medicine
;
: e7-2013.
Article
in English
| WPRIM
| ID: wpr-199827
ABSTRACT
The incidence of type 2 diabetes is rising rapidly because of an increase in the incidence of being overweight and obesity. Identification of genetic determinants for complex diseases, such as type 2 diabetes, may provide insight into disease pathogenesis. The aim of the study was to investigate the shared genetic factors that predispose individuals to being overweight and developing type 2 diabetes. We conducted genome-wide linkage analyses for type 2 diabetes in 386 affected individuals (269 sibpairs) from 171 Korean families and association analyses with single-nucleotide polymorphisms of candidate genes within linkage regions to identify genetic variants that predispose individuals to being overweight and developing type 2 diabetes. Through fine-mapping analysis of chromosome 4q34-35, we detected a locus potentially linked (nonparametric linkage 2.81, logarithm of odds 2.27, P=6 x 10-4) to type 2 diabetes in overweight or obese individuals (body mass index, BMI> or =23 kg m-2). Multiple regression analysis with type 2 diabetes-related phenotypes revealed a significant association (false discovery rate (FDR) P=0.006 for rs13144140; FDR P=0.002 for rs6830266) between GPM6A (rs13144140) and BMI and waist-hip ratio, and between NEIL3 (rs6830266) and insulin level from 1314 normal individuals. Our systematic search of genome-wide linkage and association studies, demonstrate that a linkage peak for type 2 diabetes on chromosome 4q34-35 contains two type 2 diabetes-related genes, GPM6A and NEIL3.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Chromosomes, Human, Pair 4
/
Body Mass Index
/
Statistics, Nonparametric
/
Genetic Predisposition to Disease
/
Physical Chromosome Mapping
/
Diabetes Mellitus, Type 2
/
Overweight
/
Genome-Wide Association Study
/
Genetic Loci
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2013
Type:
Article
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