Effect of Recombinant Human Granulocyte Colony-Stimulating Factor to Neutropenic Low Birth Weight Infants of Mothers with Preeclampsia / 대한소아혈액종양학회지

ABSTRACT

BACKGROUND: Almost 50% of infants born to mothers with preeclampsia have neutropenia and are at increased risk of having early-onset sepsis and nosocomial infection. In neutropenic children, recombinant human granulocyte colony-stimulating factor(rhG-CSF) increase circulating neutrophils and bone marrow neutrophil storage pools, improves neutrophil function, and results in fewer bacterial infections. We examined circulating neutrophil counts after administration of rhG-CSF to neutropenic neonates of mothers with preeclampsia. METHOD: Subjects were selected from premature(gestational age0.05). 2) Absolute neutrophil counts(ANCs) in rhG-CSF-treated infants at 24, 48 and 72 hours of age were significantly higher than initila ANCs at birth(P0.05), but significantly lower at 72 and 96 hour of age(t-test, P<0.05). 4) ANCs in rhG-CSF treated infants at 24 and 48 hours of age were significantly higher than those in control group(P<0.05), but at 72 and 96 hours of age, there were not significant difference between ANCs in treated infants and those in control group(P<0.05). Conclusoin rhG-CSF promote a rapid increase in circulating neutrophils in netropenic low birth weight infants of mothers with preeclampsia.