The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis
Experimental & Molecular Medicine
;
: 547-554, 2010.
Article
in English
| WPRIM
| ID: wpr-200111
ABSTRACT
TGF-beta-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/- APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Experimental
/
Cytokines
/
Th1 Cells
/
Inflammation Mediators
/
Collagen Type II
/
Natural Killer T-Cells
/
Antigens, CD1d
/
Immune Tolerance
/
Antibodies
/
Antibody Formation
Limits:
Animals
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2010
Type:
Article
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