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The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis
Experimental & Molecular Medicine ; : 547-554, 2010.
Article in English | WPRIM | ID: wpr-200111
ABSTRACT
TGF-beta-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/- APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Arthritis, Experimental / Cytokines / Th1 Cells / Inflammation Mediators / Collagen Type II / Natural Killer T-Cells / Antigens, CD1d / Immune Tolerance / Antibodies / Antibody Formation Limits: Animals Language: English Journal: Experimental & Molecular Medicine Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Arthritis, Experimental / Cytokines / Th1 Cells / Inflammation Mediators / Collagen Type II / Natural Killer T-Cells / Antigens, CD1d / Immune Tolerance / Antibodies / Antibody Formation Limits: Animals Language: English Journal: Experimental & Molecular Medicine Year: 2010 Type: Article