Survival Benefit of Tamoxifen in Estrogen Receptor-Negative and Progesterone Receptor-Positive Low Grade Breast Cancer Patients / 한국유방암학회지
Journal of Breast Cancer
;
: 288-295, 2012.
Article
in English
| WPRIM
| ID: wpr-200193
ABSTRACT
PURPOSE:
This study aimed to analyze the efficacy and prognostic significance of adjuvant tamoxifen in breast cancer patients with various hormone receptor statuses.METHODS:
Typically, 1,260 female breast cancer patients were recruited in this study. The correlation between estrogen receptor (ER)/progesterone receptor (PR) phenotypes and clinical characteristics was investigated, and the survival rate was assessed after 5-year follow-up.RESULTS:
The 5-year overall survival (85%) was better in women under the age of 50 years. Patients with ER+/PR+ tumors had a better 5-year survival rate (94%); those with ER-/PR- tumors experienced the worst outcome (74% survival rate); whereas single-positive cases were in between. In 97 out of 128 patients with ER-/PR+ tumors, tamoxifen was given as adjuvant hormonal therapy, and it increased the survival benefit in the lower grade group in terms of overall survival and disease-free survival (p=0.01 and p=0.03, respectively).CONCLUSION:
For high-grade tumors with ER-/PR+, adjuvant tamoxifen therapy may have no survival benefit, whereas for the patients with low-grade ER-/PR+ tumors, adjuvant tamoxifen therapy is highly suggestive.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Progesterone
/
Tamoxifen
/
Breast
/
Breast Neoplasms
/
Receptors, Progesterone
/
Survival Rate
/
Disease-Free Survival
/
Estrogens
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Breast Cancer
Year:
2012
Type:
Article
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