Localized Thymic Amyloidosis Presenting with Myasthenia Gravis: Case Report
Journal of Korean Medical Science
;
: 145-148, 2014.
Article
in English
| WPRIM
| ID: wpr-200212
ABSTRACT
A mediastinal mass was incidentally found on chest radiography in a 46-yr-old woman who had had myasthenia gravis (MG) for 2 months. Computed tomography revealed a 4-cm in size, well-defined, and lobulating mass with nodular calcification that was located in the thymus. Microscopically, the mass consisted of diffuse amorphous eosinophilic materials. These deposits exhibited apple-green birefringence under polarized light microscopy after Congo red staining. Immunohistochemical analysis revealed that they were positive for both kappa and lambda light chains and negative for amyloid A. A diagnosis of localized primary thymic amyloidosis was finally made. After thymectomy, the symptoms of MG were controlled with reduced corticosteroid requirements. Localized thymic amyloidosis associated with MG has not been reported to date.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thymectomy
/
Thymus Gland
/
Calcinosis
/
Radiography, Thoracic
/
Tomography, X-Ray Computed
/
Immunoglobulin kappa-Chains
/
Immunoglobulin lambda-Chains
/
Amyloidosis
/
Mediastinum
/
Myasthenia Gravis
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2014
Type:
Article
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