Could Vitamin E Prevent Contrast-Induced Acute Kidney Injury? A Systematic Review and Meta-Analysis
Journal of Korean Medical Science
;
: 1468-1473, 2017.
Article
in English
| WPRIM
| ID: wpr-200235
ABSTRACT
Several clinical studies have proposed a protective role for vitamin E (α-tocopherol) against contrast-induced acute kidney injury (CIAKI). The aim of study was to assess the effects of vitamin E for the prevention of CIAKI. A systematic review and meta-analysis was conducted using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. Randomized controlled trials (RCTs) reporting the effects of vitamin E on CIAKI development and measurements of renal function were included. Four trials including 623 participants were analyzed in the meta-analysis. All participants received intravenous hydration in addition to vitamin E or placebo. The incidence of the vitamin E group (5.8%) was lower than that of the control group (15.4%). Compared with the control, vitamin E significantly reduced the risk ratio (RR) of CIAKI by 62% (0.38; 95% confidence interval [CI], 0.22, 0.63; P < 0.010). In addition, vitamin E reduced serum creatinine (SCr) increase after contrast administration (standardized mean difference [SMD], −0.27; 95% CI, −0.49, −0.06; P = 0.010). However, changes in glomerular filtration rate (GFR) after contrast administration were not significantly different between vitamin E and the control group (SMD, 0.21; 95% CI, −0.01, 0.43; P = 0.060). Heterogeneity within the available trials was not observed. Our meta-analysis provides evidence that vitamin E plus hydration significantly reduced the risk of CIAKI in patients with renal impairment compared with hydration alone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vitamin E
/
Vitamins
/
Population Characteristics
/
Odds Ratio
/
Incidence
/
Contrast Media
/
Creatinine
/
Acute Kidney Injury
/
Glomerular Filtration Rate
Type of study:
Controlled clinical trial
/
Etiology study
/
Incidence study
/
Prognostic study
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2017
Type:
Article
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