The Expression of Caspase 3 and p21 in Renal Cell Carcinoma / 대한비뇨기과학회지
Korean Journal of Urology
;
: 1-6, 2002.
Article
in Korean
| WPRIM
| ID: wpr-200338
ABSTRACT
PURPOSE:
The objective of this study was to evaluate the Caspase 3 and p21 expression level and to understand the correlation between Caspase 3 expression and the clinical factors in renal cell carcinoma. MATERIALS ANDMETHODS:
Forty-two patients with renal cell carcinoma were enrolled in this study. Immunohistochemical staining of Caspase 3 and p21 was performed in formalin-fixed and paraffin-embedded tissue sections using rabbit polyclonal antibody (Caspase 3) and mouse antibody (p21). The Caspase 3 and p21 expression levels were compared with the TNM stage, Fuhrman grade, pathological type and survival rates.RESULTS:
The Caspase 3 expression level correlated only with the Fuhrman grade (p=0.017). There was no significant correlation between the Caspase 3 and p21 expression level. The prognostic values did not correlate with the Caspase 3 and p21 expression level.CONCLUSIONS:
The prognostic value of the Caspase 3 expression level in renal cell carcinoma was insufficient. The relationship between Caspase 3 and p21 was not proven in renal cell carcinoma, and new factors may be implicated with Caspase 3.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Carcinoma, Renal Cell
/
Survival Rate
/
Apoptosis
/
Caspase 3
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2002
Type:
Article
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