A Canine Model of Tracheal Stenosis Using Nd-YAG Laser / 결핵
Tuberculosis and Respiratory Diseases
;
: 54-61, 2002.
Article
in Korean
| WPRIM
| ID: wpr-200343
ABSTRACT
BACKGROUND:
Tracheal stenosis is an urgent but uncommon disease. Therefore, primary care clinicians have limited clinical experience. Animal models of a tracheal stenosis can be used conveniently for the learning, teaching, and developing new diagnostic and therapeutic modalities for tracheal stenosis. Recently, a canine model of a tracheal stenosis was developed using a Nd-YAG laser. To describe the methods and results of developed animal model, we performed this study.METHODS:
Six Mongrel dogs were generally anesthetized and the anterior 180 degree of tracheal cartilage of the animal was photo-coagulated using a Nd-YAG laser. The animals were bronchoscopically evaluated every week for 4 weeks and a pathologic evaluation was also made.RESULTS:
Two weeks after the laser coagulation, the trachea began to stenose and the stenosis progressed through 4 weeks. All animals suffered from shortness of breath, wheezing, and weight loss in the 3 weeks after the laser treatment, and two died of respiratory failure just before the fourth week. The gross pathologic findings showed the loss of cartilage and a dense fibrosis, which resulted in a fibrous stricture of the trachea. Microscopy also showed that the fibrous granulation tissue replaced destroyed cartilage.CONCLUSION:
The canine model can assist in the understanding and development of new diagnostic and therapeutic modalities for tracheal stenosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Primary Health Care
/
Respiratory Insufficiency
/
Trachea
/
Tracheal Stenosis
/
Fibrosis
/
Bronchoscopy
/
Weight Loss
/
Cartilage
/
Respiratory Sounds
/
Laser Coagulation
Limits:
Animals
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2002
Type:
Article
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