Target Effect-site Controlled Infusion of Propofol by Schnider Model: Comparison of Gender and Age / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 27-34, 2007.
Article
in Korean
| WPRIM
| ID: wpr-200365
ABSTRACT
BACKGROUND:
We investigated effect-site median effective concentration (EC50) of propofol for loss of consciousness and effect-site concentration at each anesthetic stage and awakening time to compare the differences by gender or age of patients using Schnider model.METHODS:
Total 91 patients were allocated into 4 groups male patients aged 18-34 year (Group 1), male patients aged 35-55 years (Group 2), female patients aged 18-34 years (Group 3) and female patients aged 35-55 years (Group 4). The effect-site EC50 for loss of consciousness was calculated and the effect-site concentration of propofol at each anesthetic stage and the awakening time of each group were recorded.RESULTS:
The effect-site EC50 of propofol for loss of consciousness was 4.53 +/- 0.30microgram/ml, 4.60 +/- 0.25microgram/ml, 4.13 +/- 0.39microgram/ ml and 4.47 +/- 0.65microgram/ml in group 1, 2, 3, and 4, respectively. The effect-site concentrations in male patients aged 18-34 years were significantly higher than those in female patients. The awakening time of female patients aged 35-55 years was shorter than that of male patients.CONCLUSIONS:
There were no significant differences of effect-site EC50 for the loss of consciousness of propofol with target effect-site controlled infusion by Schnider model among the groups. However the effect-site concentrations and the awakening time of propofol by Schnider model showed differences in patients' gender and age.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Unconsciousness
/
Propofol
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2007
Type:
Article
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