Relationship Between Cytogenetic Complexity and Peritumoral Edema in High-Grade Astrocytoma
Annals of Laboratory Medicine
;
: 583-589, 2016.
Article
in English
| WPRIM
| ID: wpr-200498
ABSTRACT
BACKGROUND:
The purpose of the study is to reveal the association of cytogenetic compltyexi and peritumoral edema volume (PTEV) and its prognostic significance in high-grade astrocytoma patients by culturing patient tumor cells.METHODS:
Twenty-seven high-grade astrocytoma patients were divided into three groups according to karyotype complexity normal, non-complex karyotype (NCK), and complex karyotype (CK). Endothelial growth factor receptor (EGFR) amplification was detected by FISH, and its association with chromosome 7 abnormalities was analyzed. Mean PTEV of each group was compared by ANOVA to evaluate the relationship between PTEV and cytogenetic complexity.RESULTS:
The PTEV of patients in normal (n=6), NCK (n=8), and CK (n=13) groups were 24.52±17.73, 34.26±35.04, and 86.31±48.7 cm3, respectively (P=0.005). Ten out of 11 patients with EGFR amplification showed abnormalities in chromosome 7. The mean PTEV of EGFR-amplified and non-amplified groups were 80.4±53.7 and 41.3±37.9 cm3, respectively (P=0.035). The average survival of patients with PTEV less than 90 cm3 was 30.52±26.11 months, while in patients with PTEVs over or equal to 90 cm3, it was 10.83±5.53 months (P=0.007).CONCLUSIONS:
The results show an association of complex karyotype with the PTEV of high-grade astrocytoma. EGFR amplification plays a significant role in the formation of peritumoral edema, causing PTEV to increase, which is related with survival. This implies that cytogenetic karyotype can be applied as a prognostic factor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Astrocytoma
/
Chromosomes, Human, Pair 7
/
Brain Neoplasms
/
Magnetic Resonance Imaging
/
Tumor Cells, Cultured
/
Chromosome Aberrations
/
In Situ Hybridization, Fluorescence
/
Receptors, Vascular Endothelial Growth Factor
/
Edema
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Annals of Laboratory Medicine
Year:
2016
Type:
Article
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