The Role of the Ethylacetate Fraction from Hydnocarpi Semen in Acute Inflammation In Vitro Model
Immune Network
;
: 291-295, 2012.
Article
in English
| WPRIM
| ID: wpr-20062
ABSTRACT
We previously reported that Hydnocarpi Semen (HS) has a wound healing effect on diabetic foot ulcer lesion in mice. In this study, ethylacetate (EtOAc) fraction from HS extract were evaluated for their wound healing activity by using in vitro acute inflammation model. GC and GC/MS analysis shows that the main constituents in EtOAc fraction are chaulmoogric acid, hydnocarpic acid, and gorlic acid. EtOAc fraction activated macrophages to increase the production of TNF-alpha. The fraction also increased the production of TGF-beta and VEGF, which induced fibroblast activation and angiogenesis. These results suggest that the mechanism that the fraction helps to enhance healing of skin wound is possibly associated with the production of TNF-alpha, as well as secretion of VEGF, TGF-beta and HS may have a new bioactive material for the treatment of skin wound.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Semen
/
Skin
/
Ulcer
/
Wound Healing
/
Cytokines
/
Transforming Growth Factor beta
/
Tumor Necrosis Factor-alpha
/
Diabetic Foot
/
Vascular Endothelial Growth Factor A
/
Fatty Acids
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Immune Network
Year:
2012
Type:
Article
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