Differentiating Lymphovascular Invasion from Retraction Artifact on Histological Specimen of Breast Carcinoma and Their Implications on Prognosis / 한국유방암학회지
Journal of Breast Cancer
;
: 478-480, 2012.
Article
in English
| WPRIM
| ID: wpr-200681
ABSTRACT
On a pathological specimen of breast cancer cells, retraction artifact during histological processing mimics true lymphovascular invasion (LVI). The accurate determination of the presence or absence of LVI is a factor in determining risk of having a positive sentinel node, or having additional positive axillary nodes after a positive sentinel node biopsy in women with early-stage breast cancer. The determination of nodal risk influences the decision of the treating physicians as to whether a sentinel node biopsy or completion axillary dissection is necessary. On slide preparation, ideal factors favoring true LVI include a definite endothelial lining, with endothelial nuclei that seem to protrude into the lymphatic space; invasion in one lymphatic vessel (LV) lumen with nearby cancer glands that have minimal or no retraction; a tumor embolus in a LV clear lumen with outside nearby tumor bulk; a tumor embolus that is different in shape than its surrounding clear LV space; and a positive stain for fibrin, CD31, or CD34 on tumor embolus periphery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Pyrethrins
/
Biopsy
/
Breast
/
Breast Neoplasms
/
Fibrin
/
Artifacts
/
Lymphatic Vessels
/
Embolism
/
Glycosaminoglycans
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Journal of Breast Cancer
Year:
2012
Type:
Article
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