Sulpiride in Meige's Syndrome: Possible Role of Glutamate
Yonsei Medical Journal
;
: 62-65, 1988.
Article
in English
| WPRIM
| ID: wpr-20076
ABSTRACT
Sulpiride, a selective antagonist for adenylate cyclase-independent dopamine receptors, was administrated to 25 patients with blepharospasm and oromandibular dystonia(Meige's syndrome). Of the 25, 7 patients (28%) exhibited marked and lasting improvement with sulpiride and 12 patients (48%) showed mild or transient improvement. This favorable therapeutic response to sulpiride suggests that striatal glutamate underactivity may play a role in the pathophysiology of Meige's syndrome as a primary or secondary defect.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sulpiride
/
Basal Ganglia Diseases
/
Dopamine
/
Glutamic Acid
/
Corpus Striatum
/
Glutamates
/
Meige Syndrome
/
Middle Aged
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
1988
Type:
Article
Similar
MEDLINE
...
LILACS
LIS