Alternatively activated M2 macrophages increase in early stages of experimental autoimmune myocarditis in Lewis rats / 대한수의학회지
Korean Journal of Veterinary Research
;
: 225-230, 2013.
Article
in English
| WPRIM
| ID: wpr-200775
ABSTRACT
To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically activated M1 and alternatively activated M2 macrophages, respectively, in the hearts of EAM-affected and control rats. Immunohistochemical evidence revealed that both iNOS-positive and arginase 1-positive macrophages were found in EAM lesions, while some cells were co-localized with both markers. This finding suggests that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of EAM, possibly through the reduction of nitric oxide in the lesion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arginase
/
Nitric Oxide Synthase Type II
/
Heart
/
Macrophages
/
Myocarditis
/
Nitric Oxide
Limits:
Animals
Language:
English
Journal:
Korean Journal of Veterinary Research
Year:
2013
Type:
Article
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