Reduction of Influenza A (H1N1) Virus Through a Leukoreduction Filter / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 65-73, 2010.
Article
in Korean
| WPRIM
| ID: wpr-200868
ABSTRACT
BACKGROUND:
Leukoreduction can reduce the risk of HLA alloimmunization, recurrent febrile nonhemolytic transfusion reactions, and several transfusion-transmitted infectious diseases, including cytomegalovirus infection. Transmission of the new influenza A (H1N1) virus through transfusion may be a concern. We evaluated the effect of filtration with a leukoreduction filter on H1N1 genomes.METHODS:
To evaluate the effect of filtration by a leukoreduction filter on H1N1 genomes, we analyzed pre- and post-filtered samples from nasopharyngeal swabs and 10 positive plasma samples using real time RT-PCR.RESULTS:
The 10 samples (nasopharyngeal swabs and plasma) contained H1N1 RNA, and filtration with a leukoreduction filter reduced these levels (threshold cycle values from 31.42+/-2.06 to 38.84+/-1.47 in nasopharyngeal swabs, from 35.63+/-2.19 to 39.38+/-2.65 in plasma samples).CONCLUSION:
Filtration with a leukoreduction filter can reduce H1N1 genome levels, but may not be completely sufficient for total eradication of this pathogen.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Viruses
/
Blood Group Incompatibility
/
RNA
/
Communicable Diseases
/
Genome
/
Cytomegalovirus Infections
/
Influenza, Human
/
Filtration
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
2010
Type:
Article
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