Effect of Inhaled Tiotropium on Spirometric Parameters in Patients with Tuberculous Destroyed Lung / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 167-171, 2014.
Article
in English
| WPRIM
| ID: wpr-200946
ABSTRACT
BACKGROUND:
In Korea, patients with destroyed lung due to tuberculosis (TB) account for a significant portion of those affected by chronic pulmonary function impairment. The objective of our research was to evaluate the efficacy of inhaled tiotropium bromide in TB destroyed lung.METHODS:
We compared the effectiveness of inhaled tiotropium bromide for 2 months between pre- and post-treatment pulmonary function tests performed on 29 patients with destroyed lung due to TB.RESULTS:
The mean age of the total number of patients was 63+/-9 years, where 15 patients were male. The pre-treatment mean forced expiratory volume in 1 second (FEV1) was 1.02+/-0.31 L (44.1+/-16.0% predicted). The pre-treatment mean forced vital capacity (FVC) was 1.70+/-0.54 L (52.2+/-15.8% predicted). Overall, the change in FEV1% predicted over baseline with tiotropium was 19.5+/-19.1% (p<0.001). Twenty patients (72%) got better than a 10% increase in FEV1 over baseline with tiotropium, but one patient showed more than a 10% decrease in FEV1. Overall, the change in FVC% predicted over baseline with tiotropium was 18.5+/-19.9% (p<0.001). Seventeen patients (59%) experienced greater than a 10% increase in FVC over baseline with tiotropium; 12 (41%) patients had stable lung function.CONCLUSION:
The inhaled tiotropium bromide therapy may lead to improve lung functions in patients with TB destroyed lung. However, the long-term effectiveness of this treatment still needs to be further assessed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Respiratory Function Tests
/
Tuberculosis
/
Vital Capacity
/
Forced Expiratory Volume
/
Tiotropium Bromide
/
Korea
/
Lung
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS