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The Role of Transbronchial Lung Biopsy in Diagnosing Pulmonary Mucormycosis in a Critical Care Unit / 대한중환자의학회지
Korean Journal of Critical Care Medicine ; : 205-210, 2017.
Article in English | WPRIM | ID: wpr-200976
ABSTRACT

BACKGROUND:

Pulmonary mucormycosis (PM) is an emerging infectious disease and a life-threatening infection with high mortality. The clinical outcomes of PM have not improved significantly over the last decade because early diagnosis of PM is difficult and antifungal agents show limited activity. We evaluated the clinical manifestations of PM in a Korean tertiary hospital and identified the role of transbronchial lung biopsy (TBLB) in diagnosing PM in patients admitted to an intensive care unit.

METHODS:

The medical records of adult patients (aged 16 years and older) who met the criteria for proven or probable PM in a Korean tertiary hospital were retrospectively reviewed from January 2003 to December 2013. The clinical features, computed tomographic findings, diagnostic methods, treatment, and outcomes in patients with PM were evaluated.

RESULTS:

Of the nine patients, four were male. The median age was 64 years (range, 12 to 73 years). PM was proven and probable in seven and two cases, respectively. Computed tomography findings of PM were unilateral involvement in eight cases (89%), consolidation in eight (89%), ground glass opacity in four (44%), and reverse halo sign in one (11%). Six of nine cases (67%) were diagnosed as PM from TBLB via portable bronchoscopy. There were no complications after TBLB. Mortality rate was 56% (five of nine cases).

CONCLUSIONS:

TBLB can be an easy and useful technique for diagnosing PM in the intensive care unit.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Biopsy / Bronchoscopy / Medical Records / Retrospective Studies / Mortality / Critical Care / Communicable Diseases, Emerging / Early Diagnosis / Tertiary Care Centers / Glass Type of study: Diagnostic study / Observational study / Prognostic study / Screening study Limits: Adult / Humans / Male Language: English Journal: Korean Journal of Critical Care Medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biopsy / Bronchoscopy / Medical Records / Retrospective Studies / Mortality / Critical Care / Communicable Diseases, Emerging / Early Diagnosis / Tertiary Care Centers / Glass Type of study: Diagnostic study / Observational study / Prognostic study / Screening study Limits: Adult / Humans / Male Language: English Journal: Korean Journal of Critical Care Medicine Year: 2017 Type: Article