Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells
Biomolecules & Therapeutics
;
: 121-125, 2013.
Article
in English
| WPRIM
| ID: wpr-201022
ABSTRACT
Hesperetin (3',5,7-trihydroxy 4'-methoxyflavanone) and its glycoside hesperidin (hesperetin 7-rhamnoglucoside) in oranges have been reported to possess pharmacological effects related to anti-obesity. However, hesperetin and hesperidin have not been studied on suppressive effects on appetite. This study examined that hesperetin and hesperidin can stimulate the release of cholecystokinin (CCK), one of appetite-regulating hormones, from the enteroendocrine STC-1 cells, and then examined the mechanisms involved in the CCK release. Hesperetin significantly and dose-dependently stimulated CCK secretion with an EC50 of 0.050 mM and increased the intracellular Ca2+ concentrations ([Ca2+]i) compared to the untreated control. The stimulatory effect by hesperetin was mediated via the entry of extracellular Ca2+ and the activation of TRP channels including TRPA1. These results suggest that hesperetin can be a candidate biomolecule for the suppression of appetite and eventually for the therapeutics of obesity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Appetite
/
Cholecystokinin
/
Enteroendocrine Cells
/
Citrus sinensis
/
Hesperidin
/
Obesity
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2013
Type:
Article
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