Gingival absorption of α-tocopherol acetate and 18β-glycyrrhetinic acid : in vitro evaluation in reconstructed gingival tissue / 대한구강보건학회지
Journal of Korean Academy of Oral Health
;
: 79-84, 2016.
Article
in English
| WPRIM
| ID: wpr-201071
ABSTRACT
OBJECTIVES:
To assess the absorption of α-tocopherol acetate and 18β-glycyrrhetinic acid, which are used as active ingredients in toothpaste, into a reconstructed gingival tissue.METHODS:
EpiGingival™ tissues were treated with a 25% slurry of toothpaste containing 2% α-tocopherol acetate and 0.3% 18β-glycyrrhetinic acid, for 2 minutes. The treatment was repeated up to 6 times, with 1 hour intervals. After completion of all treatments, the active ingredients in the tissue extracts and receiver solutions were measured by high performance liquid chromatography.RESULTS:
Although α-tocopherol acetate was not detected, α-tocopherol was detected in the tissue extracts, indicating that α-tocopherol acetate was bioconverted to α-tocopherol after absorption. We could detect 18β-glycyrrhetinic acid both in the tissue extracts and in the receiver solutions, with a positive correlation to the number of treatments.CONCLUSIONS:
We found that our toothpaste effectively delivered α-tocopherol acetate and 18β-glycyrrhetinic acid to a reconstructed gingival tissue in vitro.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontal Diseases
/
Tissue Extracts
/
Toothpastes
/
In Vitro Techniques
/
Chromatography, Liquid
/
Absorption
Language:
English
Journal:
Journal of Korean Academy of Oral Health
Year:
2016
Type:
Article
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