Antiviral Therapy in Patients after Treatment for Hepatitis C-Related Hepatocellular Carcinoma
Gut and Liver
;
: 77-81, 2011.
Article
in English
| WPRIM
| ID: wpr-201094
ABSTRACT
BACKGROUND/AIMS:
Despite great progress, antiviral treatment for chronic hepatitis C in patients with prior hepatocellular carcinoma (HCC) has been rarely investigated. We evaluated the efficacy and safety of antiviral therapy following treatment for hepatitis C-related HCC.METHODS:
Thirteen patients (age 34 to 60 years) who were treated with peginterferon plus ribavirin after treatment for HCC were reviewed.RESULTS:
There were 6 patients with genotype 1 and 7 patients with genotype 2. All patients showed advanced fibrosis (> or =F3) but belonged to the Child-Pugh class A. Treatment was stopped in 2 patients because of recurrent HCC and in 1 patient due to a lack of early virologic response. Seven patients achieved sustained virologic response and three patients relapsed. The sustained virologic response rate was 54% overall, 17% in genotype 1, and 86% in genotype 2. No significant adverse events were reported.CONCLUSIONS:
Antiviral therapy should not be excluded in patients who were previously treated with HCC with genotype 2 chronic hepatitis C, in which an efficacious antiviral treatment for chronic hepatitis C was feasible. Additional study is needed to prove the validity of antiviral therapy in patients with genotype 1 hepatitis C-related HCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ribavirin
/
Fibrosis
/
Carcinoma, Hepatocellular
/
Hepatitis C, Chronic
/
Genotype
/
Hepatitis
Limits:
Humans
Language:
English
Journal:
Gut and Liver
Year:
2011
Type:
Article
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