The Prognostic Value of the Tumor Shrinkage Rate for Progression-Free Survival in Patients with Non-Small Cell Lung Cancer Receiving Gefitinib / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 315-320, 2015.
Article
in English
| WPRIM
| ID: wpr-20115
ABSTRACT
BACKGROUND:
The efficacy of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) therapy can be measured based on the rate of treatment response, based on the Response Evaluation Criteria in Solid Tumors (RECIST) criteria or progression-free survival (PFS). However, there are some patients harboring sensitive EGFR mutations who responded poorly to EGFR-TKI therapy. In addition, there is variability in the PFS after EGFR-TKI treatment.METHODS:
We performed a retrospective analysis of the medical records of 85 patients with non-small cell lung cancer, who had achieved a stable disease or better response at the first evaluation of treatment response, after receiving a 2-month course of gefitinib. We calculated the tumor shrinkage rate (TSR) by measuring the longest and perpendicular diameter of the main mass on computed tomography before, and 2 months after, gefitinib therapy.RESULTS:
There was a significant positive correlation between the TSR and PFS (R=0.373, p=0.010). In addition, a simple linear regression analysis showed that the TSR might be an indicator for the PFS (B+/-standard error, 244.54+/-66.79; p=0.001). On univariate analysis, the sex, histologic type, smoking history and the number of prior chemotherapy regimens, were significant prognostic factors. On multivariate regression analysis, both the TSR (beta=0.257, p=0.029) and adenocarcinoma (beta=0.323, p=0.005) were independent prognostic factors for PFS.CONCLUSION:
Our results showed that the TSR might be an early prognostic indicator for PFS in patients receiving EGFR-TKI therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Protein-Tyrosine Kinases
/
Adenocarcinoma
/
Smoking
/
Linear Models
/
Medical Records
/
Retrospective Studies
/
Carcinoma, Non-Small-Cell Lung
/
Disease-Free Survival
/
Drug Therapy
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2015
Type:
Article
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