Molecular Classification of Triple-Negative Breast Cancer / 한국유방암학회지
Journal of Breast Cancer
;
: 223-230, 2016.
Article
in English
| WPRIM
| ID: wpr-201281
ABSTRACT
Tumor heterogeneity of triple-negative breast cancer (TNBC) has been the main barrier in conquering breast cancer. To dissect the molecular diversity of TNBC and discover therapeutic targets for TNBC, the molecular classification of TNBC is a prioritized issue in research area. Accordingly, recent studies have been successful in classifying TNBC into several distinct subtypes with specific biologic pathways. Despite the different methodologies used and varied number of final subtypes, these studies identically suggested that TNBC consists of four major subtypes basal-like, mesenchymal, luminal androgen receptor, and immune-enriched. By reviewing these methods of classifications of TNBC, we highlight the unmet need to develop a molecular classifier suited for TNBC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenobarbital
/
Population Characteristics
/
Breast Neoplasms
/
Receptors, Androgen
/
Gene Expression
/
Classification
/
Triple Negative Breast Neoplasms
Language:
English
Journal:
Journal of Breast Cancer
Year:
2016
Type:
Article
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