In Vitro Effects of Combined Antibiotics against Multidrug-resistant Pseudomonas aeruginosa / 대한내과학회지
Korean Journal of Medicine
;
: 41-47, 2010.
Article
in Korean
| WPRIM
| ID: wpr-201333
ABSTRACT
BACKGROUND/AIMS:
The inhibitory effects of the combination of beta-lactam with ciprofloxacin or amikacin against clinical isolates of multidrug-resistant Pseudomonas aeruginosa were evaluated.METHODS:
This study examined ten isolates with variable levels of resistance to ceftazidime, cefepime, piperacillin/tazobactam, meropenem, ciprofloxacin, and amikacin. The efficacy of the combined antibiotics was studied using a checkerboard method or in vitro killing assay.RESULTS:
The combination of ceftazidime, cefepime, aztreonam, piperacillin-tazobactam, or meropenem with amikacin showed synergistic effects for all of the strains regardless of the minimum inhibitory concentration (MIC) of amikacin, but combination with ciprofloxacin showed a synergistic effect for the isolate with a low MIC of ciprofloxacin by the checkerboard method. The isolates with a high MIC of ciprofloxacin showed an indifferent effect in combination with beta-lactam and ciprofloxacin. The in vitro killing assay showed that meropenem with ciprofloxacin acted synergistically for the isolates with a MIC of 16 microgram/mL of ciprofloxacin. However, amikacin showed synergistic effects with meropenem for the isolates with high-level resistance against amikacin, i.e., up to an MIC of 128 microgram/mL. Contrary to the checkerboard method results, no synergy was observed for the combination of ceftazidime/piperacillin-tazobactam and amikacin.CONCLUSIONS:
Meropenem with amikacin can be the first choice for infections caused by multidrug-resistant P. aeruginosa when the level of resistance is not known.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pseudomonas
/
Pseudomonas aeruginosa
/
Aztreonam
/
Amikacin
/
Ciprofloxacin
/
Microbial Sensitivity Tests
/
Ceftazidime
/
Cephalosporins
/
Thienamycins
/
Homicide
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS