De Novo Light Chain Deposition Disease in Long-term Survived Renal Allograft / 대한신장학회지
Korean Journal of Nephrology
;
: 539-543, 2010.
Article
in Korean
| WPRIM
| ID: wpr-201342
ABSTRACT
Light chain deposition disease (LCDD) is characterized by the deposition of abnormal immunoglobulin light chains in many organs, including kidney. It is usually associated with multiple myeloma or other lymphoproliferative disorders. Myeloma usually occurs in old age and may develop after renal transplantation thus being categorized as posttransplant lymphoproliferative disease (PTLD). Renal LCDD usually presents with variable degree of proteinuria and renal insufficiency. The diagnosis of LCDD depends on histologic findings with detection of monoclonal immunoglobulin light chain. Histologically, it is characterized by nodular glomerulosclerosis. We report the first case of de novo LCDD associated with myeloma after renal transplantation in Korea. With advancing renal transplantation and increasing old aged renal recipients, myeloma or LCDD should be included in the differential diagnoses of renal recipient patients with deteriorating renal function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Proteinuria
/
Transplantation, Homologous
/
Kidney Transplantation
/
Immunoglobulin Light Chains
/
Diabetic Nephropathies
/
Diagnosis, Differential
/
Renal Insufficiency
/
Kidney
/
Korea
/
Light
Type of study:
Diagnostic study
Limits:
Aged
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Nephrology
Year:
2010
Type:
Article
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