TACI:Fc scavenging B cell activating factor (BAFF) alleviates ovalbumin-induced bronchial asthma in mice
Experimental & Molecular Medicine
;
: 343-352, 2007.
Article
in English
| WPRIM
| ID: wpr-201420
ABSTRACT
Asthma was induced by the sensitization and challenge with ovalbumin (OVA) in mice. B-cell activating factor (BAFF) plays a role in mature B cell generation and maintenance. Here, we investigated whether, BAFF expression was changed in OVA-induced mice and whether the control of BAFF expression level alleviates the symptom of bronchial asthma. BAFF expression was detected in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues. BAFF protein was also increased in OVA-induced mouse serum. The increased BAFF transcripts was detected in OVA-induced mouse splenocytes. OVA-induced asthma was associated with the increased number of eosinophils in bronchoalveolar lavage fluid (BALF). When TACIFc scavenging soluble BAFF was injected to OVA-induced mice, a significant inhibition was detected in the thickness of airway smooth muscle and glycol-containing cellular elements in airway that were visualized by hematoxylin/eosin Y and periodic acid-Schiff staining, respectively. In addition, when mice were treated with TACIFc protein, BAFF protein level was decreased in alveolar-associated cells surrounding bronchi of OVA-induced mouse lung tissues compared to control mice. When compared to OVA-induced control, TACIFc treatment reduced the percentage of non-lymphoid cells and no changes were detected in lymphoid cell population. Hypodiploid cell formation in BALF was decreased by OVA-challenge but it was recovered by TACIFc treatment. Collectively, data suggest that asthmatic symptom could be alleviated by scavenging BAFF and then BAFF could be a novel target for the develpoment of anti-asthmatic agents.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pulmonary Alveoli
/
Asthma
/
Spleen
/
Recombinant Fusion Proteins
/
Bronchi
/
Immunoglobulin G
/
Immunoglobulin Fc Fragments
/
Bronchoalveolar Lavage Fluid
/
Lymphocytes
/
Ovalbumin
Limits:
Animals
/
Female
/
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS