Effects of retinoic acid on ischemic brain injury-induced eurogenesis
Experimental & Molecular Medicine
;
: 304-315, 2007.
Article
in English
| WPRIM
| ID: wpr-201424
ABSTRACT
Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Tretinoin
/
Brain
/
Cell Differentiation
/
Ischemic Attack, Transient
/
Neuroglia
/
Rats, Sprague-Dawley
/
Cell Proliferation
/
Neovascularization, Pathologic
/
Neurons
Limits:
Animals
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2007
Type:
Article
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