Seizures in Children Receiving Cancer Treatment / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 119-125, 2011.
Article
in Korean
| WPRIM
| ID: wpr-201484
ABSTRACT
BACKGROUND:
The neurological complications of childhood patients with cancer are caused by brain metastasis, chemotherapy, and infection. Seizure is one of the most important neurological complications of pediatric patients receiving chemotherapy. This study was designed to identify the causes, clinical manifestations, and prognosis of seizures in children receiving cancer treatment.METHODS:
We retrospectively reviewed the medical records of pediatric cancer patients with seizures at Pusan National University Hospital from January 2005 to December 2010.RESULTS:
Among 271 patients, 31 experienced seizures (19 males and 12 females), and the mean age at the first seizure was 8.6 years (1.7-18.0 years). Seizures frequently occurred in patients with brain tumors (27.8%), and the types of seizures were generalized seizure in 15 patients (48.4%) and partial in 16 cases (51.6%). Eighteen (62.0%) of 29 patients who underwent a brain magnetic resonance imaging study and 21 (75.0%) of 28 cases who received an electroencephalogram recorded abnormal findings. The causes of seizures were drugs, CNS infections, and brain metastasis each in five cases (16.2%). Drugs were the most common cause in patients with a hematological malignancy (16.2%), whereas brain metastasis was the most common cause in patients with solid tumors (12.9%). Eight (40.0%) of 20 patients who survived received anticonvulsants. Eleven patients (35.5%) expired, and the most common cause of death was progression of the malignancy.CONCLUSION:
Drugs, CNS infection, and brain metastasis of tumors were the most common causes of seizure in children with malignancy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Seizures
/
Brain
/
Brain Neoplasms
/
Magnetic Resonance Imaging
/
Medical Records
/
Retrospective Studies
/
Cause of Death
/
Hematologic Neoplasms
/
Electroencephalography
Type of study:
Observational study
/
Prognostic study
Limits:
Child
/
Humans
/
Male
Language:
Korean
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2011
Type:
Article
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