Prevalence of Porphyromonas gingivalis fimA genotypes in the peri-implant sulcus of Koreans assessed using a new primer
Journal of Periodontal & Implant Science
;
: 35-45, 2016.
Article
in English
| WPRIM
| ID: wpr-201529
ABSTRACT
PURPOSE:
Porphyromonas gingivalis fimA is a virulence factor associated with periodontal diseases, but its role in the pathogenesis of peri-implantitis remains unclear. We aimed to evaluate the relationship between the condition of peri-implant tissue and the distribution of P. gingivalis fimA genotypes in Koreans using a new primer.METHODS:
A total of 248 plaque samples were taken from the peri-implant sulci of 184 subjects. The control group consisted of sound implants with a peri-implant probing depth (PD) of 5 mm or less with no bleeding on probing (BOP). Test group I consisted of implants with a peri-implant PD of 5 mm or less and BOP, and test group II consisted of implants with a peri-implant PD of more than 5 mm and BOP. DNA was extracted from each sample and analyzed a using a polymerase chain reaction (PCR) with P. gingivalis-specific primers, followed by an additional PCR assay to differentiate the fimA genotypes in P. gingivalis- positive subjects.RESULTS:
The Prevalence of P. gingivalis in each group did not significantly differ (P>0.05). The most predominant fimA genotype in all groups was type II. The prevalence of type Ib fimA was significantly greater in test group II than in the control group (P<0.05).CONCLUSIONS:
The fimA type Ib genotype of P. gingivalis was found to play a critical role in the destruction of peri-implant tissue, suggesting that it may be a distinct risk factor for peri-implantitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontal Diseases
/
Virulence
/
DNA
/
Polymerase Chain Reaction
/
Prevalence
/
Risk Factors
/
Porphyromonas
/
Porphyromonas gingivalis
/
Virulence Factors
/
Peri-Implantitis
Type of study:
Etiology study
/
Prevalence study
/
Risk factors
Language:
English
Journal:
Journal of Periodontal & Implant Science
Year:
2016
Type:
Article
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