Esthesioneuroblastoma in a boy with 47, XYY karyotype / 소아과
Korean Journal of Pediatrics
;
: S92-S95, 2016.
Article
in English
| WPRIM
| ID: wpr-201852
ABSTRACT
Neuroblastomas are sometimes associated with abnormal constitutional karyotypes, but the XYY karyotype has been rarely described in neuroblastomas. Here, we report a case of an esthesioneuroblastoma in a boy with a 47, XYY karyotype. A 6-year-old boy was admitted to our hospital because of nasal obstruction and palpable cervical lymph node, which he first noticed several days previously. A polypoid mass in the right nasal cavity was detected through sinuscopy. Biopsy of the right nasal polyp was performed. Based on the result, the patient was diagnosed with a high-grade esthesioneuroblastoma. Nuclear imaging revealed increased uptake in both the right posterior nasal cavity and the right cervical IB-II space, suggesting metastatic lymph nodes. Cytogenetic analysis revealed a 47, XYY karyotype. Twelve courses of concurrent chemotherapy were administered. Three years after the completion of chemotherapy, the patient had had no disease recurrence. He manifested behavioral violence and temper tantrums, so we started methylphenidate for correction of the behavior.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Violence
/
XYY Karyotype
/
Biopsy
/
Nasal Obstruction
/
Nasal Polyps
/
Chromosome Aberrations
/
Esthesioneuroblastoma, Olfactory
/
Cytogenetic Analysis
/
Drug Therapy
Limits:
Child
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2016
Type:
Article
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