Change of Renal Function and Morphology in 3/4 Nephrectomized Rats / 대한비뇨기과학회지

ABSTRACT

To examine the effect renal mass reduction on compensatory renal hypertrophy and progressive glomerular sclerosis, 3/4 nephrectomy was performed in mature male rats. Serial changes in renal histology and function were investigated at weeks 1, 2, 6 and 12 after 3/4 nephrectomy. Mean glomerular diameter increased 29% during the first week thereafter the growth rate of glomeruli was similar to that of sham operated control's. Peak renal function was achieved at 6 weeks and thereafter progressively decreased. The prominent glomerular sclerosis was found at 12th week. These results suggest that renal growth after renal mass reduction is a pathologic process ensuing progressive renal damage.