Your browser doesn't support javascript.
loading
COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway in human bladder cancer cells
Experimental & Molecular Medicine ; : 199-203, 2005.
Article in English | WPRIM | ID: wpr-201942
ABSTRACT
Cyclooxygenase-2 (COX-2) has been reported to be associated with tumor development and progression as well as to protect cells from apoptosis induced by various cellular stresses. Through a tetracycline-regulated COX-2 overexpression system, we found that COX-2 inhibits detachment-induced apoptosis (anoikis) in a human bladder cancer cell line, EJ. We also found that the inhibition of anoikis by COX-2 results from activation of the PI-3K/Akt pathway as evidenced by suppression of the COX-2 effect on anoikis by a PI-3K inhibitor, LY294002. Furthermore, COX-2 enhanced Mcl-1 expression in the anoikis process, implying that Mcl-1 also may be involved in mediating the survival function of COX-2. Together, these results suggest that COX-2 inhibits anoikis by activation of the PI-3K/Akt pathway and probably by enhancement of Mcl-1 expression in human bladder cancer cells. This anti- anoikis effect of COX-2 may be a part of mechanisms to promote tumor development and progression.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Urinary Bladder Neoplasms / Tumor Cells, Cultured / Transfection / Signal Transduction / Proto-Oncogene Proteins / Prostaglandin-Endoperoxide Synthases / Protein Serine-Threonine Kinases / Proto-Oncogene Proteins c-bcl-2 / Anoikis / Enzyme Activation Limits: Humans Language: English Journal: Experimental & Molecular Medicine Year: 2005 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Urinary Bladder Neoplasms / Tumor Cells, Cultured / Transfection / Signal Transduction / Proto-Oncogene Proteins / Prostaglandin-Endoperoxide Synthases / Protein Serine-Threonine Kinases / Proto-Oncogene Proteins c-bcl-2 / Anoikis / Enzyme Activation Limits: Humans Language: English Journal: Experimental & Molecular Medicine Year: 2005 Type: Article