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Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-kappaB-signaling Pathway
Article in English | WPRIM | ID: wpr-202114
Responsible library: WPRO
ABSTRACT
Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular H2O2-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-alpha- and interleukin-6-induced nuclear factor-kappaB activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WCE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WCE may be a promising topical anti-inflammatory agent.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants / Regeneration / Skin / Sodium Dodecyl Sulfate / Humans / RNA, Messenger / NF-kappa B / Reactive Oxygen Species / Eleocharis / Erythema Language: English Journal: Biomolecules & Therapeutics Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants / Regeneration / Skin / Sodium Dodecyl Sulfate / Humans / RNA, Messenger / NF-kappa B / Reactive Oxygen Species / Eleocharis / Erythema Language: English Journal: Biomolecules & Therapeutics Year: 2015 Type: Article