Evaluation of Cerebral Metabolism for Children Undergoing Open Heart Surgery for Atrial Septal Defect Using Proton Magnetic Resonance Spectroscopy
Korean Circulation Journal
;
: 155-162, 2002.
Article
in Korean
| WPRIM
| ID: wpr-202284
ABSTRACT
BACKGROUND AND OBJECTIVES:
The purpose of this study was to investigate whether a brief cardiopulmonary by-pass, with mild hypothermia and normal flow, would have any deleterious effects on brain metabolism in children. This is the first study using localized in vivo proton magnetic resonance spectroscopy (1H-MRS) in brains of children with ASD undergoing open-heart surgery (OHS). SUBJECTS ANDMETHODS:
Seven children undergoing surgical closure of ASD, with mild hypothermia and normal flow cardiopulmonary by-pass, were studied. Their ages ranged from 18 to 47 months, and body weights ranged from 11 to 17 kg. We performed 1H-MRS before OHS, and 1-3 months after, then compared the values of brain metabolite ratios before and after surgery. The values from our patients were compared to those from 12, age-matched, normal children. All MR imaging, and localized 1H-MRS, were performed using a GE 1.5T SIGNA system (General Electric Medical System, Milwaukee, USA). Image guided STEAM-spectra were obtained from, the parietal white matter (PWM), and occipital gray matter (OGM), with TE of 30 msec, and TR of 3 sec, using a PROton Brain Exam (PROBE) (General Electric Medical System, Milwaukee, USA).RESULTS:
All metabolite ratios, measured by 1H-MRS, from patients before surgery showed no significantly difference from postoperative values. However, [choline/creatine] ratios, obtained from PWM, were higher in both pre- and postoperative ASD patients, as compared to those of normal children.CONCLUSION:
We concluded, that brain metabolism, measured by 1H-MRS, does not change significantly after OHS, for children with ASD, with mild hypothermia and normal flow.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protons
/
Thoracic Surgery
/
Body Weight
/
Brain
/
Magnetic Resonance Imaging
/
Magnetic Resonance Spectroscopy
/
Cardiopulmonary Bypass
/
Rabeprazole
/
Heart
/
Heart Septal Defects, Atrial
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Circulation Journal
Year:
2002
Type:
Article
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