Expression of Neuropeptides and Their Receptors in Psoriatic Lesions / 대한피부과학회지
Korean Journal of Dermatology
;
: 1191-1194, 2006.
Article
in Korean
| WPRIM
| ID: wpr-20231
ABSTRACT
BACKGROUND:
Neuroimmunocutaneous system alteration can be responsible for the induction and maintenance of the inflammatory process of psoriasis.OBJECTIVE:
This study was carried out to examine the expression of Substance P (SP), calcitonin gene-related peptide (CGRP), somatostatin (SOM), neutral endopeptidase (NEP), SP receptor, and CGRP receptor in psoriatic lesions.METHODS:
A skin biopsy was obtained from 10 psoriatic patients and 10 normal control subjects. Confocal laser scanning microscopy was performed.RESULTS:
The SP and CGRP receptors consistently increased in psoriatic lesions, compared to the normal controls.CONCLUSION:
The increased expression of neuropeptides and their receptors may be involved in the pathogenesis of psoriasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psoriasis
/
Skin
/
Biopsy
/
Neuropeptides
/
Somatostatin
/
Neprilysin
/
Substance P
/
Calcitonin Gene-Related Peptide
/
Receptors, Neuropeptide
/
Receptors, Calcitonin Gene-Related Peptide
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2006
Type:
Article
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