DA-9701: A New Multi-Acting Drug for the Treatment of Functional Dyspepsia
Biomolecules & Therapeutics
;
: 181-189, 2013.
Article
in English
| WPRIM
| ID: wpr-202366
ABSTRACT
Motilitone(R) (DA-9701) is a new herbal drug that was launched for the treatment of functional dyspepsia in December 2011 in Korea. The heterogeneous symptom pattern and multiple causes of functional dyspepsia have resulted in multiple drug target strategies for its treatment. DA-9701, a compound consisting of a combination of Corydalis Tuber and Pharbitidis Semen, has being developed for treatment of functional dyspepsia. It has multiple mechanisms of action such as fundus relaxation, visceral analgesia, and prokinetic effects. Furthermore, it was found to significantly enhance meal-induced gastric accommodation and increase gastric compliance in dogs. DA-9701 also showed an analgesic effect in rats with colorectal distension induced visceral hypersensitivity and an antinociceptive effect in beagle dogs with gastric distension-induced nociception. The pharmacological effects of DA-9701 also include conventional effects, such as enhanced gastric emptying and gastrointestinal transit. The safety profile of DA-9701 is also preferable to that of other treatments.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Relaxation
/
Semen
/
Gastrointestinal Transit
/
Compliance
/
Corydalis
/
Dyspepsia
/
Nociception
/
Gastric Emptying
/
Analgesia
Limits:
Animals
Country/Region as subject:
Asia
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2013
Type:
Article
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