Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model
Biomolecules & Therapeutics
;
: 454-461, 2013.
Article
in English
| WPRIM
| ID: wpr-202594
ABSTRACT
The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Brain Injuries
/
Reperfusion
/
Neuroprotective Agents
/
Middle Cerebral Artery
/
Stroke
/
Infarction, Middle Cerebral Artery
/
Rosa
/
Cyclooxygenase 2
/
Nitric Oxide Synthase Type II
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS