Expression of Actin-bundling Protein Fascin and its Relationship with Altered E-cadherin and beta-catenin Expressions in Ovarian Serous Neoplasms
Korean Journal of Pathology
;
: 258-264, 2005.
Article
in English
| WPRIM
| ID: wpr-202810
ABSTRACT
Background:
Fascin, an actin-bundling protein, has been found in specialized normal cells, including the neuronal, endothelial and dendritic cells, and its expression is known to be greatly increased in various human neoplasms.Methods:
Immunohistochemical stainings for fascin, betacatenin, and E-cadherin were performed in normal ovary tissue (n=13), and in benign (n=14), borderline (n=32), and malignant (n=74) ovarian serous neoplasms. We evaluated the fascin expression, and its relationship with the betacatenin and E-cadherin expressions, as well as the clinicopathologic factors.Results:
Fascin expression was detected in the majority of the borderline (100%, 32/32) and malignant tumors (90.5%, 67/74), but it was not seen in the normal ovarian surface epithelial cells and the benign tumors (p<0.001). Fascin expression was significantly correlated with the occurrence of peritoneal metastases in the carcinomas (p=0.043). A significant relationship between the expressions of fascin and betacatenin (p=0.046), as well as E-cadherin (p=0.035) was noted. There was no significant correlation with the tumor grade of carcinoma, the FIGO stage, tumor recurrence, tumor-related death and the survival rate.Conclusions:
In ovarian serous neoplasms, the fascin expression may be closely linked with tumor progression and metastasis, and it was associated with the up-regulation of betacatenin and E-cadherin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovary
/
Recurrence
/
Dendritic Cells
/
Cadherins
/
Up-Regulation
/
Survival Rate
/
Epithelial Cells
/
Beta Catenin
/
Neoplasm Metastasis
/
Neurons
Limits:
Female
/
Humans
Language:
English
Journal:
Korean Journal of Pathology
Year:
2005
Type:
Article
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