The efficacy of oral contraceptive pre-treatment in controlled ovarian hyperstimulation using a GnRH antagonist in low responders / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 987-995, 2005.
Article
in Korean
| WPRIM
| ID: wpr-202936
ABSTRACT
OBJECTIVE:
This study was performed to evaluate the efficacy of GnRH antagonist multidose protocol (GnRH-ant MDP) with or without oral contraceptive (OC) pretreatment in low responders undergoing IVF-ET, compared with standard GnRH agonist (GnRH-a) lowdose long protocol (LP).METHODS:
Eighty-two patients, aged 28-42 years who were defined as low responders were recruited for this prospective study and they were randomized to undergo GnRH-ant MDP after OC pretreatment (group 1) or GnRH-ant MDP without OC pretreatment (group 2) or GnRH-a luteal lowdose LP (group 3). All of the subjects were administered recombinant human FSH (rhFSH) for ovarian stimulation.RESULTS:
Patients' characteristics were comparable among three groups. Total dose and duration of rhFSH used for COH were significantly higher in group 3 than those in group 1 or 2. The number of mature oocytes, fertilization rate and the number of grade I, II embryos were significantly lower in group 2 than those in other groups. The clinical pregnancy rate seemed to be lower in group 2 but the difference did not achieve statistical significance. There were also no differences in the miscarriage rate and multiple pregnancy rate among three groups.CONCLUSION:
This study demonstrates that GnRH-ant MDP with OC pretreatment is as effective as GnRH-a lowdose LP and might be considered more advantageous because of the short-term and small dose application in low responders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oocytes
/
Ovulation Induction
/
Pregnancy, Multiple
/
Abortion, Spontaneous
/
Prospective Studies
/
Gonadotropin-Releasing Hormone
/
Pregnancy Rate
/
Follicle Stimulating Hormone, Human
/
Embryonic Structures
/
Fertilization
Type of study:
Controlled clinical trial
/
Practice guideline
/
Observational study
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2005
Type:
Article
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