Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain
Clinical and Experimental Vaccine Research
;
: 114-118, 2015.
Article
in English
| WPRIM
| ID: wpr-203143
ABSTRACT
We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing antibodies were raised 5-6 days after the virus challenge. The utilization of O Manisa as a safe vaccine strain will increase if recombinant viruses can be manipulated by inserting or removing a marker gene for differential serology or replacing the protective gene from another serotype.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parents
/
Swine
/
Virulence
/
Goats
/
Clone Cells
/
Cloning, Molecular
/
DNA, Complementary
/
Foot-and-Mouth Disease Virus
/
Antibodies, Neutralizing
/
Foot-and-Mouth Disease
Limits:
Animals
/
Humans
Language:
English
Journal:
Clinical and Experimental Vaccine Research
Year:
2015
Type:
Article
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