Effect of a Flavon Extracted from Artemisia absinthium on Collagen Induced Arthritis in Mice / 소아과
Korean Journal of Pediatrics
;
: 677-684, 2004.
Article
in English
| WPRIM
| ID: wpr-203173
ABSTRACT
PURPOSE:
In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated.METHODS:
DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies and a stimulation index of the splenocytes of the mice were measured. IL-10 and TNF-alpha in the supernatants of the mice sera were measured by ELISA. mRNA expression for IL-10 and TNF-alpha in the splenocytes were tested.RESULTS:
Flavon extracted from Artemisia absinthium appears to be an effective suppressor of CIA in mice. The serum anti-collagen antibody level and stimulation index of the cultured splenocytes showed no significant differences among the three experimental groups. Also serum IL-10 and TNF-alpha levels did not show any significant differences among the three experimental groups. An increased expression of mRNA for IL-10 was observed in the splenocytes treated with flavon.CONCLUSION:
With these results, flavon extracted from Artemisia absinthium appears to have a suppressive effect of CIA. The mechanism of the suppressive effect of flavon extracted from Artemisia absinthium may be from a stimulation of IL-10 production.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis
/
Arthritis, Experimental
/
RNA, Messenger
/
Enzyme-Linked Immunosorbent Assay
/
Chickens
/
Incidence
/
Collagen
/
Immunization
/
Tumor Necrosis Factor-alpha
/
Interleukin-10
Type of study:
Incidence study
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2004
Type:
Article
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