Correlation of Mast Cell Densities, Angiogenesis and Vascular Endothelial Growth Factor in Proper Muscle Gastric Carcinomas / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 41-45, 2002.
Article
in Korean
| WPRIM
| ID: wpr-203238
ABSTRACT
PURPOSE:
There are increasing evidences that angiogenesis enhances tumor growth and biological aggressiveness in gastric carcinoma. Mast cells have been implicated in the angiogenic process, by secreting angiogenic factors including vascular endothelial growth factor (VEGF), or enzymes that degrade extracellular matrices. However, the exact nature of mast cells in relation to cancer is contradictory so we conducted retrospective studies, to find the significance of mast cell densities, and microvessel counts in each clinicopathologic factors, including VEGF expression, in proper muscle (PM) gastric carcinoma. MATERIALS ANDMETHODS:
52 specimens, obtained from patients with PM gastric carcinoma, were studied using the immunohistochemical methods, monoclonal antibodies for mast cell tryptase, factor VIII-related antigen and VEGF.RESULTS:
Mast cell densities were significantly increased in diffuse histologic type (p=0.042), infiltrating margins (p3 cm (p=0.015), diffuse histologic type (p=0.038) and lymph node metastasis (p=0.001). Similarly there were significantly increased densities in VEGF positive tumors (p<0.0001). Pearson's correlation analysis revealed a significant relationship between mast cell densities and microvessel counts (r=0.614, p<0.01), indicating a high vascular grade with increased number of mast cells.CONCLUSION:
We demonstrated a close relationship between mast cell densities, microvessel counts and VEGF expression. These results suggest that mast cells and VEGF are important regulators of tumor angiogenesis and cooperatively induce the formation of vascular stroma in PM gastric carcinomas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stomach Neoplasms
/
Von Willebrand Factor
/
Retrospective Studies
/
Vascular Endothelial Growth Factor A
/
Angiogenesis Inducing Agents
/
Extracellular Matrix
/
Tryptases
/
Microvessels
/
Lymph Nodes
/
Mast Cells
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Cancer Research and Treatment
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS