Efficacy of Combination Chemotherapy with Paclitaxel and Cisplatin in Patients with Advanced Non-Small Cell Lung Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 28-33, 2002.
Article
in Korean
| WPRIM
| ID: wpr-203240
ABSTRACT
PURPOSE:
To evaluate the efficacy and toxicity of the combination therapy of paclitaxel and cisplatin in advanced, non-small cell, lung cancer patients MATERIALS ANDMETHODS:
Between December 1997 and September 2001, 37 patients with advanced, non-small cell, lung cancer were enrolled in this study. Patients were treated with paclitaxel (135 mg/m2, 24 hr infusion) and cisplatin (75 mg/m2). The treatments were repeated every 4 weeks.RESULTS:
Among the 37 patients enrolled, 21 were treated with paclitaxel and cisplatin as a first-line and 16 patients as a second-line. The median age of the patients was 59. In the first-line group, 10 had stage IIIB and 11 had stage IV, non small cell lung cancer. Of 21 patients in first-line treatment group that could be evaluated, objective responses were observed in 6 patients (response rate 28.6%, CR 4.8%, PR 23.8%). The mediansurvival duration for patients was 48 weeks. With the second-line group, 3 patients showed a partial response (response rate 18.7%) to treatment, with median survival duration of 44 weeks. Grade 3-4 leukopenia was observed in 27.1% of the first-line, and 23.6% in second- line, treatment groups.CONCLUSION:
Combination chemotherapy, with paclitaxel and cisplatin, in non-small cell lung cancer has acceptable toxicities in both first and second-line treatment groups. In terms of efficacy, no superior response was shown for either group. More randomized studies, with a larger group of patients, are required to prove the true efficacy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cisplatin
/
Paclitaxel
/
Carcinoma, Non-Small-Cell Lung
/
Drug Therapy, Combination
/
Small Cell Lung Carcinoma
/
Leukopenia
/
Lung Neoplasms
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Korean
Journal:
Cancer Research and Treatment
Year:
2002
Type:
Article
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