A Study of Natural Killer Cell Activities , T Cells and T Cell Subsets in Vitiligo / 대한피부과학회지

ABSTRACT

The pathogenesis of vitiligo is still unresolved. The three classically held theories are the immune hypothesis, neural hypothesis, and self destruct hypothesis. Recently the immunologic hypothesis is the most important. We analysed natural killer cell activities of 30 cases of vitiligo by Cr release assay, also analysed T cells and T cell subsets of 7 cases of vitiligo in peripheral blood by monoclonal antibody. The result were as follows l. A statistically significant increase of natural killer cell activity was observed in patients with vitiligo(67.5+/-19.2%) in comparison with control subjects(54.7+/-14.7%) 2. 5lo significant difference of natural killer cell activity was observed in patients whose onset of disease was less than 1 year(66.2+/-19.6%) in comparison with more than 1 year(72.0+/-18.4%) 3. No significant difference of natural killer cell activity was observed in patients with vitiligo between generalized(68.3+/-20.6) and localized type(70.3+/-18.0%). 4. The mean value of T cell, T cell subsets(T3, T4, TS) in patients with vitiligo(78. 8+/-10.8, 42.4+/-6.1, 26.46.8%) showed no significant difference in comparison with control subjects(75.3+/-6.3, 43.5+/-8.7, 26.1+/-6.69).