Identification of Hypoxanthine and Phosphoenolpyruvic Acid as Serum Markers of Chemoradiotherapy Response in Locally Advanced Rectal Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 78-89, 2015.
Article
in English
| WPRIM
| ID: wpr-20373
ABSTRACT
PURPOSE:
Patients show variable responses to chemoradiotherapy (CRT), which is generally administered before surgery for locally advanced rectal cancer (LARC). The aim of this study was to identify molecular markers predictive of CRT responses by analysis of low-mass ions (LMIs) in serum of LARC patients. MATERIALS ANDMETHODS:
LMIs ( 16.0 muM showed significant association with ypStage 0-1 or TRG 4-3 than ypStage 3-4 (p=0.009) or TRG 1 (p=0.024), respectively. In contrast, a significantly lower concentration of PEP was observed in TRG 4-3 compared with TRG 2-1 (p=0.012).CONCLUSION:
Findings of this study demonstrated that serum concentrations of HX and PEP, identified using LMI profiling, may be useful for predicting the CRT response of LARC patients before treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphoenolpyruvate
/
Rectal Neoplasms
/
Mass Spectrometry
/
Biomarkers
/
Hypoxanthine
/
Metabolome
/
Enzyme Assays
/
Chemoradiotherapy
/
Ions
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2015
Type:
Article
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