Metachronous Double Primary Cancer after Treatment of Breast Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 64-71, 2015.
Article
in English
| WPRIM
| ID: wpr-20375
ABSTRACT
PURPOSE:
The pattern of double primary cancer after treatment for breast cancer is important for patient survival. MATERIALS ANDMETHODS:
We analyzed 108 cases of metachronous double primary cancer in breast cancer patients treated from 1999 to 2012.RESULTS:
Metachronous double primary cancers occurred in 108 of 2,657 patients (4.1%) with breast cancer. The median time to the occurrence of second cancer after diagnosis of the first was 58.4+/-41.2 months (range, 6.9 to 180.2 months). The most common cancer was thyroid cancer, which occurred in 45 patients (41.7%). This was followed by gastric cancer in 16 patients (14.8%), endometrial cancer in 10 patients (9.3%), and cervical cancer in seven patients (6.5%). The relative risk showed a significant increase in endometrial (4.78; 95% confidence interval [CI], 1.66 to 13.79), gastric (2.61; 95% CI, 1.68 to 4.06), and thyroid cancer (1.95; 95% CI, 1.37 to 2.79). At 5 years after diagnosis of breast cancer, secondary cancer occurred in 48 patients (44.4%), with 50.0% of the endometrial, 56.3% of the stomach, and 37.8% of the thyroid cancer cases being diagnosed after 5 years. Median survival after diagnosis of the second cancer was 123.9+/-11.2 months. The prognosis was mainly influenced by the anatomic site.CONCLUSION:
The incidence of endometrial, stomach, and thyroid cancer increased significantly after treatment with primary breast cancer, and survival was dependent on early detection and the type of second primary cancer. A prolonged follow-up examination for metachronous double primary cancer is needed to provide early detection and improve survival time in patients with breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Stomach
/
Stomach Neoplasms
/
Breast Neoplasms
/
Thyroid Neoplasms
/
Uterine Cervical Neoplasms
/
Incidence
/
Neoplasms, Second Primary
/
Endometrial Neoplasms
/
Diagnosis
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Prognostic study
/
Screening study
Limits:
Female
/
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2015
Type:
Article
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