Additive Effect of Pronase on the Eradication Rate of First-Line Therapy for Helicobacter pylori Infection
Gut and Liver
;
: 340-345, 2015.
Article
in English
| WPRIM
| ID: wpr-203893
ABSTRACT
BACKGROUND/AIMS:
Helicobacter pylori colonizes on the apical surface of gastric surface mucosal cells and the surface mucous gel layer. Pronase is a premedication enzyme for endoscopy that can disrupt the gastric mucus layer. We evaluated the additive effects of pronase combined with standard triple therapy for H. pylori eradication.METHODS:
This prospective, single-blinded, randomized, controlled study was conducted between June and October 2012. A total of 116 patients with H. pylori infection were enrolled in the study (n=112 patients, excluding four patients who failed to meet the inclusion criteria) and were assigned to receive either the standard triple therapy, which consists of a proton pump inhibitor with amoxicillin and clarithromycin twice a day for 7 days (PAC), or pronase (20,000 tyrosine units) combined with the standard triple therapy twice a day for 7 days (PACE).RESULTS:
In the intention-to-treat analysis, the eradication rates of PAC versus PACE were 76.4% versus 56.1% (p=0.029). In the per-protocol analysis, the eradication rates were 87.5% versus 68.1% (p=0.027). There were no significant differences concerning adverse reactions between the two groups.CONCLUSIONS:
According to the interim analysis of the trial, pronase does not have an additive effect on the eradication of H. pylori infection (ClinicalTrial.gov NCT01645761).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drug Administration Schedule
/
Pronase
/
Single-Blind Method
/
Prospective Studies
/
Helicobacter pylori
/
Helicobacter Infections
/
Treatment Outcome
/
Clarithromycin
/
Drug Therapy, Combination
/
Proton Pump Inhibitors
Type of study:
Controlled clinical trial
/
Practice guideline
/
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Gut and Liver
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS