Subcutaneous Panniculitis-Like T-cell Lymphoma: A Clinical and Pathologic Study of 14 Korean Patients
Annals of Dermatology
;
: 329-337, 2011.
Article
in English
| WPRIM
| ID: wpr-204015
ABSTRACT
BACKGROUND:
Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a distinctive skin lymphoma characterized by neoplastic T-cell infiltration of the subcutaneous tissue, mimicking panniculitis.OBJECTIVE:
To describe the clinical and pathologic features of SPTL in Korean patients.METHODS:
Fourteen SPTL patients evaluated over 15 years were retrospectively reviewed.RESULTS:
The mean patient age was 35 years (range 7~73 years), with male predominance (2.51). Most patients presented with either nodules or plaques, occurring most commonly on the trunk, with two patients (14%) having hemophagocytic syndrome. Histopathologically, all patients showed infiltrates of small-to-medium pleomorphic cells mimicking panniculitis, with some also showing rimming, bean-bag cells, and fat necrosis. Most patients were positive for CD3 (14/14), CD8 (12/13), TIA-1 (9/9) and betaf1 (5/5), but were negative for CD4 (11/12), CD20 (8/8), CD56 (14/14) and Epstein-Barr virus (8/8). Ten patients (71%) received chemotherapy and 2 (14%) died due to the disease, with an average survival time of 4 months. Survival analysis did not reveal any significant prognostic factors.CONCLUSION:
This is the first series of patients with SPTL in Korea. Due to its indolent clinical course and relatively high survival rate, SPTL should be differentiated from cutaneous gammadelta T-cell lymphoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin
/
T-Lymphocytes
/
Panniculitis
/
Survival Rate
/
Retrospective Studies
/
Lymphoma, T-Cell
/
Herpesvirus 4, Human
/
Subcutaneous Tissue
/
Lymphohistiocytosis, Hemophagocytic
/
Fat Necrosis
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Annals of Dermatology
Year:
2011
Type:
Article
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