A Double-blinded, Randomized, Placebo Controlled Study of the Effect a Small Dose of Ketamine has on Postoperative Pain of Sevoflurane-remifentanil Anesthesia / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 146-151, 2008.
Article
in Korean
| WPRIM
| ID: wpr-204182
ABSTRACT
BACKGROUND:
Remifentanil is a useful and relatively safe opioid, but acute tolerance to it frequently develops, as patients who have received remifentanil based anesthesia often suffer postoperative hyperalgesia.This study investigated whether a small dose of ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, can attenuate postoperative pain suffered with remifentanil anesthesia.METHODS:
32 patients who were scheduled to undergo laparoscopic cholecystectomy were randomly assigned to two groups a ketamine group (group K) and a control group (group C).All patients were given remifentanil by target controlled infusion (TCI) to the effect site (concentrations4.0-6.0 ng/ml).Just before incision patients in group K received 0.15 mg/kg ketamine intravenously and patients in group C received the same volume, but only of normal saline.Pain scores measured by Numerical Rating Scale (NRS) and additional use of analgesics were immediately recorded by a blinded investigator at the post-anesthesia care unit (PACU) and general ward up to 24 hours after surgery.RESULTS:
The average NRS scores upon arrival to PACU, 5, 10, 15 and 30 min in PACU, and 5 hours after discharge from PACU were significantly lower in group K than group C.The frequency of additional analgesics use was also significantly lower in group K.CONCLUSIONS:
It is suggested that a small dose of ketamine attenuates the postoperative pain felt with remifentanil anesthesia. This finding also suggests that ketamine may decrease the possible acute tolerance developed with remifentanil anesthesia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain, Postoperative
/
Piperidines
/
Research Personnel
/
Patients' Rooms
/
N-Methylaspartate
/
Cholecystectomy, Laparoscopic
/
Hyperalgesia
/
Analgesics
/
Anesthesia
/
Ketamine
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2008
Type:
Article
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