Glutathione S-transferase M1, T1 and P1 Gene Polymorphisms and Carotid Atherosclerosis in Korean Patients with Rheumatoid Arthritis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 166-175, 2003.
Article
in Korean
| WPRIM
| ID: wpr-204537
ABSTRACT
OBJECTIVE:
We assessed the contribution of genetic polymorphisms of glutathione S-transferase M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1, Ile105Val) to carotid atherosclerosis in 40 postmenopausal rheumatoid arthritis (RA) women without histories of smoking.METHODS:
We measured mean intima-media thickness (IMT) and plaque of the common carotid arteries by ultrasonography, and evaluated relations among the known risk factors for atherosclerosis, genetic polymorphisms, RA outcomes and markers of inflammation.RESULTS:
Subjects with the GSTT1-null genotype had greater IMT (p<0.05). On univariate analysis, carotid IMT was positively associated with age, systolic BP, antihypertensive drug use and the GSTT1-null genotype (p<0.05). When compared to subjects with a double- positive GSTM1/T1 genotype, IMT in subjects with concurrent lack of the GSTM1 and GSTT1 gene was significantly increased (p=0.008).CONCLUSION:
This study suggests that the GSTT1-null genotype might have an interaction with carotid atherosclerosis related to RA in Korean postmenopausal RA women free of smoking history.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Arthritis, Rheumatoid
/
Smoke
/
Carotid Artery Diseases
/
Smoking
/
Risk Factors
/
Ultrasonography
/
Carotid Artery, Common
/
Atherosclerosis
/
Genotype
Type of study:
Diagnostic study
/
Etiology study
/
Risk factors
Limits:
Female
/
Humans
Language:
Korean
Journal:
The Journal of the Korean Rheumatism Association
Year:
2003
Type:
Article
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